Lossofheterozygositysomaticmutation

由 K Takahashi 著作 · 2021 — Conclusions: This study suggests that in advanced malignant soft tissue tumors, accumulation of genome-wide LOH of germline mutations/variants ...

2019年11月13日 — Somatic Mutations and Loss of Heterozygosity of HLA Genes Are Frequently Occurred and Tightly Associated with Poor Prognosis in Adult T Cell ...

由 GL Ryland 著作 · 2015 · 被引用 164 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

Loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal ...

由 CA Nichols 著作 · 2020 · 被引用 81 次 — LOH occurs when a cancer cell that is originally heterozygous at a locus loses one of its two alleles at that locus, either by simple deletion ...

由 JA Tischfield 著作 · 1997 · 被引用 144 次 — sequent somatic alteration (or mutation, in the broadest sense) in the remaining normal allele, and its absolute certainty of occurrence causes the trait ...

由 X Zhang 著作 · 2021 · 被引用 42 次 — Loss of heterozygosity (LOH) is a common genetic event in the development of cancer and is known to play an essential role in the somatic loss ...

由 SWP Wijnhoven 著作 · 2001 · 被引用 49 次 — Loss of heterozygosity (LOH) of tumour suppressor genes is a crucial step in the development of sporadic and hereditary cancer. Recently, we and others have ...

Loss of heterozygosity (LOH) occurs when a somatic cell contains only one of the two traditional alleles at a genetic locus. LOH may be the result of the ...